MME Calculator (Morphine Milligram Equivalents)
Add up your daily opioid dose in morphine milligram equivalents (MME) using the 2022 CDC conversion factors. Example: oxycodone 20 mg twice a day (40 mg) is 60 MME per day, above the 50 MME level where extra caution and naloxone are advised.
Show steps
How to use the MME Calculator (Morphine Milligram Equivalents)
- Enter the values in the fields.
- Press Calculate to see the result with the steps shown.
Formula and method
Daily MME = total daily dose (mg) x conversion factor. CDC 2022 factors: codeine 0.15, hydrocodone 1, oxycodone 1.5, morphine 1, hydromorphone 5, oxymorphone 3, tapentadol 0.4, tramadol 0.2, methadone 4.7, fentanyl patch 2.4 per mcg/hour.
CDC 2022 conversion factors
| Opioid | Factor |
|---|---|
| Morphine | 1 |
| Hydrocodone | 1 |
| Codeine | 0.15 |
| Oxycodone | 1.5 |
| Oxymorphone | 3 |
| Hydromorphone | 5 |
| Tapentadol | 0.4 |
| Tramadol | 0.2 |
| Methadone | 4.7 |
| Fentanyl patch (mcg/hour) | 2.4 |
What MME levels mean
| Daily MME | Guidance (CDC) |
|---|---|
| Under 50 | Lower risk; use the lowest effective dose |
| 50 to 89 | Reassess benefit and risk; offer naloxone |
| 90 or more | Higher overdose risk; seek expert review |
Examples
| Regimen | Daily MME |
|---|---|
| Hydrocodone 5 mg four times a day | 20 |
| Oxycodone 10 mg three times a day | 45 |
| Tramadol 50 mg four times a day | 40 |
| Morphine ER 30 mg twice a day | 60 |
| Fentanyl patch 25 mcg/hour | 60 |
Safety first
Naloxone reverses an opioid overdose and is available without a prescription in the US. Store opioids locked and out of reach. This calculator is for education and is not medical advice. Never change or start a medicine without the advice of a pharmacist or prescriber, and always follow the label.
Frequently asked questions
What is MME?
The strength of an opioid dose expressed as the equivalent amount of oral morphine.
What MME is high?
90 or more per day is a high-risk level in CDC guidance.
Can I use MME to switch opioids?
No; conversion between opioids needs clinician judgement.
Why is methadone special?
Its potency varies with dose and it can affect heart rhythm.
Is buprenorphine included?
No; its conversion is not recommended.
Where can I get naloxone?
Pharmacies, health departments and some programs.
Sources
- CDC: Clinical Practice Guideline for Prescribing Opioids for Pain, 2022
- CDC: Calculating total daily dose of opioids
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